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Recent studies have indicated that an application of antibiotic along with low power ultrasound can decrease the viability of planktonic bacteria by several orders of magnitude. The combination of ultrasound with antibiotics released from bone cement decreases the viability of planktonic and biofilm bacteria.[i] Herein we investigated a similar application of spectinomycin and ultrasound to the Gram-negative bacteria Escherichia coli (E. coli). The antibiotic concentration is just below that of the Minimal Inhibitory Concentration (MIC) and the ultrasound is of minimal inhibitory effect on E. coli. [ii]
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Enhancement of Antibiotic Action with an Application of
Ultrasound 01/05/2007 |