Natalie Raso - Weapons of Targeted Destruction: Using Viruses to Kill Cancer
    Bibliography

Project Information

Abstract

Project Summary

Background

Purpose

Scientific Thought

Hypotheses

Apparatus and Materials

Genetically Engineered KM110red Herpesvirus


Methodology

Procedure for Cell-Line Splitting

Procedure for KM110r Infection

Procedure for Immunofluorescent
Microscopy Imaging


Statistical Analyses

Proliferation Assay Analyzed Data

Major Results

Graphed Results

Discussion of Statistics

Controls and Variables

Conclusions

Discussion

Discussion of KM110r Efficacy

Successes and Failures

Sources of Error and Data

Limitations


Future Research

Applications

Glossary

Bibliography

Acknowledgements
 

"Virus (life science)," Microsoft® Encarta® Online Encyclopedia 2005
 © 1997-2005 Microsoft Corporation. All Rights Reserved
.

 

Chen, XW; Garner, SC; Anderson, JJ. 2002. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen- receptor -dependent pathway. Biochemistry Biophysics Research Communication. 295:417-22

 

Chiocca, A. E. 2002. Oncolytic Viruses. Nature Reviews Cancer. 2:938-951.

 

Everett, RD. 2000. ICP0, a regulator of herpes simplex virus during lytiv and latents infection. Bioessays. 22:761-70.

 

Felts, KA; Chen, K; Zaharee, K; Sundar, L; Limjoco, J; Miller, A; Vaillancourt, P. 2002. Functional cloning using pFB retroviral cDNA expression libraries. Journal of Molecular Biotechnology. 22(1):25-28

 

Hamid Ali, S; DeCaprio, JA. 2002. Cellular transformation by SV40 large T antigen: interaction with host proteins. Seminars in Cancer Biology. 11:15-23

 

Harris, S; Enger, RJ; Riggs, BL; Spelsburg, TC. 1995. Development and Characterization of a Conditionally Immortalized Human Fetal Osteoblastic Cell Line. Journal of Bone and Mineral Research. 10:178-186.

 

Heldin CH , et al. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. 1986. Nature 319: 511-514.

 

Hofbauer, LC; Hicok, KC; Chen, D; Khosla, S. 2002. Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells. European Journal of Endocrinology. 147:269-73.

 

Kapoor, P; Saunders, MM; Li, Z; Zhou, Z; Sheaffer, N; Kunze, El; Samant, RS; Welch, DR; Donahue, HJ. 2004. Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. International Journal of Cancer. 111:693-7.

 

Lim, JY; Liu, X; Vogler, EA; Donahue, HJ. 2004. Systematic variation in osteoblast adhesion and phenotype with substratum surface characteristics. Journal of Biomedical Material Research. 68A:504-12

 

Lisignoli, G; Toneguzzi, S; Cattini, L; Pozzi, C; Facchini A. 1998. Different expression pattern of cytokine receptors by human osteosarcoma cell lines. International Journal of Oncology. 12(4):899-903

 

Macias, CL; Willliams, K; Baccetti, B; Renieri, T; Reddi, H; Asseffa, A; Hollis, V; Grissom, F; Anderson, W. 2002. Culture and co-culture of DU145 prostate carcinoma, osteoblasts and HT-29 colon carcinoma cells on a fabricated type III collagen matrix. Journal of Submicroscopic Cytologocial Pathology. 34:241-53.

 

Maran, A; Zhang, M; Kennedy, AM; Sibonga, JD; Rickard, DJ; Spelsburg, TC, Turner, RT. 2002. 2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells. Journal of Bone Research. 30:393-8

 

Mossman, K. L., Smiley, J. R. 1999. Truncation of the C-Terminal Acidic transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0. Journal of Virology. 73: 9726-9733.

 

Nelissen, JM; Torensma, R; Pluyter, M; Adema, GJ; Raymakers, RA; van Kooyk, Y; Figdor, CG. 2000. Molecular analysis of the hamatopoiesis supporting osteoblastic cell line U2OS. Elsevier Science. 28(4):422-32

 

Ring, J. A. M. 2002. Cytolytic viruses as potential anti-cancer agents. Journal of General Virology. 83:491-502.

 

Schmidmaier, G; Wildemann, B; Lubberstedt, M; Haas, NP; Raschke, M. 2003. IGF-I and TGF-beta 1 incorporated in a poly (D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation inc ell culture. Journal of Biomedical Material Research. 65B:157-62

 

Spelsberg, TC; Harris, SA. Immortalized human fetal osteoblastic cells. US Patent 5,681,701 dated Oct 28 1997

 

Subramaniam, M; Jalal, SM; Rickard, DJ; Harris, SA; Bolander, ME; Spelsburg, TC. 2002. Further Characterization of Human Fetal Osteoblastic hFOB 1.19 and hFOB/ERalpha Cells: Bone Formation In Vivo and Karyotype Analysis Using Multicolor Fluorescent In Situ Hybridization. Journal of Cellular Biochemistry. 87:9-15.

 

Varghese, S; Rabkin, SD. 2002. Oncolytic herpes simplex virus vectors for cancer biotherapy. Cancer and Gene Therapy. 9:967-978

 

Villarreal, L. P. (2004, December). Are Viruses Alive? Scientific American, 291: 100—105.

 

Yu DC, Working P, and Ando D. 2002. Selectively replicating oncolytic adenoviruses as cancer therapeutics. Current Opinion in Molecular Therapeutics. 4:435-443.

 

Hummel, J. Personal Interview. 8 October 2004

Hummel, J. Personal Interview. 13 November 2004.

Hummel, J. Personal Interview. 15 December 2004.

Hummel, J. Personal Interview. 20 January 2005.

Hummel, J. Personal Interview. 10 February 2005

Hummel, J. Personal Interview. 25 February 2005

Hummel, J. Personal Interview. 7 March 2005.

Hummel, J. Personal Interview. 15 March 2005.

Hummel, J. Personal Interview. 23 March 2005.

Mossman, K. Personal Interview. 8 October 2005

Mossman, K. Personal Interview. 15 December 2005

Mossman, K. Personal Interview. 10 February 2005

Mossman, K. Personal Interview. 23 March 2005

 

Hummel, J. “RE: A few more questions” E-mail to the author. 2 March 2005

Hummel, J. “RE: A few questions” E-mail to the author. 11 March 2005.

Hummel, J. “RE: Question” E-mail to the author. 16 March 2005.

Hummel, J. “Some Info” E-mail to the author. 17 March 2005.

Mossman, K. “Some useful information” E-mail to the author. 13 December 2004.

Mossman, K. “Revision advice” E-mail to the author. 24 March 2005


Back to Home Page - Natalie Raso