| Natalie Raso - Weapons of Targeted Destruction: Using Viruses to Kill Cancer | Applications |
| Project
Information Abstract Project Summary Background Purpose Scientific Thought Hypotheses Apparatus and Materials Genetically Engineered KM110red Herpesvirus Methodology Procedure for Cell-Line Splitting Procedure for KM110r Infection Procedure for Immunofluorescent Microscopy Imaging Statistical Analyses Proliferation Assay Analyzed Data Major Results Graphed Results Discussion of Statistics Controls and Variables Conclusions Discussion Discussion of KM110r Efficacy Successes and Failures Sources of Error and Data Limitations Future Research Applications Glossary Bibliography Acknowledgements |
This research will
open new possibilities in the therapy of cancer. The usefulness of the discoveries found in this
experiment includes: ·
KM110r can be a
powerful tool in combating cancer. Because of its specificity, it may
prove to be more advantageous over the currently used anticancer drugs
which invariably have unwanted toxic side effects. KM110r will only target
the osteosarcoma cells without interfering with early precursor cells as
they progress to terminally differentiated cells. ·
As a cancer therapy, use of KM110r is
optimal when administered at 37°C —or physiological body temperature—since
34°C conditions delay cell destruction, and 39°C conditions do not permit
successful termination of the cancerous cells. Therefore, the
effectiveness of KM110r as an oncolytic virus therapy could be severely
impaired if the body temperature of the cancer patient becomes
hyperthermic or hypothermic, i.e. the patient spikes a fever or
experiences dangerously low body temperatures, respectively. A patient with a fever may need an
analgesic administered along with the KM110r
therapy. ·
KM110r is
worth developing into an oncolytic virus therapy In the near future,
KM110r can be adopted as a promising therapy against
cancer. |