Bibliography

 

Barzilai, A. & Melamed, E. (2003). Molecular mechanisms of selective dopaminergic neuronal deathin Parkinson’s disease. Trends in Molecular Medicine. 9: 126-132

Bennet, M. Catherine, (2004). The role of α-synuclein in Neurodegenerative Diseases. Pharmacology & Therapeutics: Article in Press.

Christjanson, L.J., Middlemiss, P.J., & Rathbone, M.P. (1993). Stimulation of Astrocyte Proliferation by Purine and Pyrimidine Nucleotides and Nucleosides. Glia 7: 176-182.

Ciccarelli, R. et al. (2001). Involvement of Astrocytes in Purine-Mediated Reparative Processes in the Brain. Int. J. Devl. Neuroscience 19: 393-414.

Cummings, Jeffrey L. et al. The Neuropsychiatry of Alzheimer’s Disease and Related Dementias. London: Martin Dunitz Ltd., 2003.

Hashimoto, Makoto, et al. (2003). Trangenic Models of α-synuclein Pathology: Past, Present, and Future. Annals New York Academy of Science 991: 171-188.

Health Canada & Parkinson Society Canada. Parkinson’s Disease: Social and Economic Impact. June 2003.

Hengartner, M. (2000). The biochemistry of apoptosis. Nature 407: 770-776

Hindley, S., Herman, M.A.R., & Rathbone, M.P. (1994). Stimulation of Reactive Astrogliosis In Vivo by Extracellular Adenosine Diphosphate or an Adenosine A2 Receptor Agonist. Journal of Neuroscience Research 38: 399-406.

Huang, Yue et al. (2004). Genetic contributions to Parkinson’s disease. Brain Research Reviews 46: 44-70.

Jessen, Kristjan R. (2004). Cells in Focus: Glial Cells. International Journal of Biochemistry and Cell Biology 36: 1861-1867.

Kalivendi, K.V. et al. (2004). α-Synuclein Up-regulation and Aggregation during MPP+- induced Apoptosis in Neuroblastoma Cells. Journal of Biological Chemistry 279: 15240-15247.

Kim, J.K., Rathbone, M.P, Middlemiss, P.J., Hughes, D.W., & Smith, R.W. (1991). Purinergic Stimulation of Astroblast Proliferation: Guanosine and Its Nucleotides Stimulate Cell Division in Chick Astroblasts. Journal of Neuroscience Research 28: 442-455.

Matthew, Maureen. Parkinson’s Research Update. Parkinson Society Canada. 2003

Middlemiss, P.J., Rathbone, M.P., & Gysbers, J.W. (1995). Extracellular Guanosine and Guanosine-5'-Triphosphate Increase: NGF Synthesis and Release From Culutred Mouse Neopallial Astrocytes. Brain Research 677: 152-156.

Neary, J.T., Rathbone, M.P., Cattabeni, F., Abbracchio, M.P., & Burnstock, G. (1996). Trophic Actions of Extracellular Nucleotides and Nucleosides on Glial and Neuronal Cells. Trends Neurosci. 19: 13-15.

Nicotra, A. & Parvez, S.H. (2002) Apoptotic molecules and MPTP-induced cell death. Neurotoxicology and Teratology 24: 599-605.

Parkinson Society Canada. Quick Facts about Parkinsons. Date of publication unknown.

Pettifer, Kathleen M. et al. (2004). Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis.

Rathbone, M.P. et al. (1998). The Trophic Effects of Purines and Purinergic Signalling in Pathologic Reactions of Astrocytes. Alzheimer Disease and Associated Disorders 12 (2): S36-S45.

Rathbone, M.P., Middlemiss, P.J., Gysbers, J.W., DeForge, S., Costello, P, Del Maestro, R. (1992). Purine Nucleosides and Nucleotides Stimulate Proliferation of a Wide Range of Cell Types. In Vitro Cell. Dev. Bio. 28A: 529-536.

Rathbone, M.P., Middlemiss, P.J., Gysbers, J.W., Andrew, C., Herman, M.A.R., Reed, J.K., Ciccarelli, R., Di Iorio, P., & Caciagli, F. (1999). Trophic Effects of Purines in Neurons and Glial Cells. Progress in Neurobiology 59: 663-690.

Rathbone, M.P. et al. (1998). Physiology and Pharmacology of Natural and Synthetic Nonadenine-Based Purines in the Nervous System. Drug Development Research 45: 356-372.

Rathbone, M.P., Middlemiss, P.J., Kim, J.K.,Gysbers, J.W., DeForge, S., Hughes, D.W., & Smith, R.W. (1992). Adenosine and its Nucleotides Stimulate Proliferation of Chick Astrocytes and Human Astrocytoma Cells. Neuroscience Research 13: 1-17.

Yuan, J. & Yankner, B.A. (2000). Apoptosis in the nervous system. Nature 407: 802-809


Effects of Guanosine on Alpha-Synuclein in a Parkinson's Disease Model

Menu

Project Info

Abstract

Background

Purpose

Hypothesis

Tissue Culture

Cell Extraction of Protein

ELISA Procedure

BCA Protein Assay Procedure

Observations

Statistical Analysis

Conclusion

Discussion

Applications

Acknowledgements

Bibliography

Home