Acknowledgements

• Kate Pettifer from McMaster University, for all her time, assistance, and support.

• Dr. Michel Rathbone from McMaster University, for allowing me to work in his lab, and providing help and encouragement.

• Dr. Eva Werstiuk, Dr. Shucui Jiang, Dr. Raelene Rathbone, and Christian Bau from McMaster University for their assistance and encouragement.

• My parents, Michelle and Stephen Martin, for their encouragement and financial support.

• Dr. Margaret Fahnestock for referring me to Dr. Rathbone and encouraging me.

• Ms. Assalone and Ms. Kolmanic, my science fair mentors from Bishop Ryan Highschool, for their encouragement and help with science fair registration. Also, a special thank you to Ms. Assalone for her advice on website design and photo resolution.

• Everyone from Dr. Rathbone’s lab at McMaster University for welcoming and encouraging me.

• Parkinson Society Canada for providing me with information.

Photo Acknowledgements

All pictures of Patrick Martin were taken by Kate Pettifer. All other pictures in the lab were taken by Patrick Martin.

Neuron background from www.bcm.ulaval.ca/ accueil.aspx?tabid=115

SH-SY5Y Neuroblastoma Cell picture from http://www.axiope.com/catalogs/expts-eve-lutz/lists/File/1.html

MPP+ Chemical Structure from http://www.neurosci.pharm.utoledo.edu/MBC3320/dopamine.htm

Guanosine Chemical Structure from http://www.otterbein.edu/home/fac/DNHJHNS/chem220/tutorial4/nucleotides.htm

Effects of Guanosine on Alpha-Synuclein in a Parkinson's Disease Model

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Project Info

Abstract

Background

Purpose

Hypothesis

Tissue Culture

Cell Extraction of Protein

ELISA Procedure

BCA Protein Assay Procedure

Observations

Statistical Analysis

Conclusion

Discussion

Applications

Acknowledgements

Bibliography

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