Introduction

 

 

No matter how unlikely they may seem, accidents can occur, and all steps should be taken to analyze the possible implications of these accidents. As nuclear power plants become more and more popular in the world, it is important to fully understand the effects that an accidental radiation exposure can have on humans and the environment. One way we can assess this risk in humans is to evaluate the changes that occur in chromosomes when human cells are exposed, in vitro (in the test-tube), to radiation.

 

When exposed to radiation, breaks in the chromosomes in cells can occur. These breaks are most often correctly repaired, but very rarely, they may not be repaired, resulting in chromosome(s) with rearrangements. When rearrangements occur between two different chromosomes, they are known as interchromosomal rearrangements (translocations), whereas, intrachromosomal rearrangements (inversions) occur within a single chromosome. The greater the number of these aberrations, the greater the amount of radiation (the dose) the cells have been exposed to. Therefore, by measuring the frequency of chromosomal alterations within a sample of cells, one can determine the dose that the cells have received.


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