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In reviewing the findings, it appears that the niacin alleviated the symptoms reported by the participants. It is possible that this allergy-symptom relief is related to niacin's effect on the release of histamine.
Histamine plays a significant role in the body's response to allergens. In the review of the literature, there appears to be evidence linking the effects of niacin and histamine. Niacin and histamine may interact with, and/or counteract, one another. Literature reports the following:
· Both niacin and histamine have significant effects on the circulatory system. For example, histamine increases the permeability of blood vessels (e.g., hives) while niacin causes blood vessels to dilate (e.g., the hot red flush).
· The literature reports that niacin can lessen the severity of migraine headaches. This is significant for allergy sufferers, as their symptoms can also include headaches.
· While histamine causes a decrease in blood pressure, niacin increases circulation. An increased circulation helps to raise blood pressure. Therefore, niacin can counteract the effect of decreased blood pressure caused by histamine.
· Niacin works to regulate normal secretion of stomach fluids and bile. This is important since histamine stimulates gastric secretion. In fact, a niacin deficiency includes gastrointestinal problems.
· Histamine causes inflammation and irritation of the skin. Niacin is an important nutritional element in keeping skin healthy.
· Niacin assists in the functioning of the nervous system. Histamine stimulates nerve endings, e.g., the itch related to an insect bite.
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