The Intestinal Diseases Research Program (IDRP) at McMaster University, Dr. Richard D. Hunt, Professor of Medicine, Division of Gastroenterology, and Dr. Rene Padol, for their complete support of my work including access to laboratory, equipment and the opportunity to learn and grow. Their interest, support and patience have been overwhelming.

Jennifer Dai, Biostatistician, Firestone Institute for Respiratory Health, St. Joseph’s Health Care, for assistance and guidance with statistical analyses.

M. Bruni and R. Macaluso, histology technicians at McMaster University for their help regarding tissue samples.

Mentors E. Irwin, S. Walker, and J. Teoh for their valuable guidance.

A. Chiarelli for priceless assistance regarding web design.

My mother and father for their ongoing help and support.