Results
1. All three drugs are inhibit breast cancer viability at micromolar concentrations; however, all three drugs are dose dependant. All three drugs are most effective at a concentration of 0.1µM, although Mibefradil exhibits the greatest effect, followed by Pimozide and Tamoxifin.
Effects of Mibefradil, Pimozide and Tamoxifin on the
Proliferation and Growth of
Breast Cancer Cells
2. All drugs were cytotoxic for the MCF-7 cell line, however, the pathway of cell death differed. Mibefradil and Tamoxifin induced to die primarily from necrosis, while Pimozide induced the majority of cells to undergo apoptosis.
Apoptotic Cell Death of Breast Cancer Cells in the
Presence of Pimozide, Mibefradil and Tamoxifin
Necrotic Cell Death of Breast Cancer Cells in the
Presence of Pimozide, Mibefradil and Tamoxifin
A Comparison of Apoptotic and Necrotic Deaths
